Abstract
Nowadays, the use of marine by-products as precursor materials has gained great interest in the extraction and production of chemical compounds with suitable properties and possible pharmaceutical applications. The present paper presents the development of a new immediate release tablet containing calcium lactate obtained from Black Sea mussel shells. Compared with other calcium salts, calcium lactate has good solubility and bioavailability. In the pharmaceutical preparations, calcium lactate was extensively utilized as a calcium source for preventing and treating calcium deficiencies. The physical and chemical characteristics of synthesized calcium lactate were evaluated using Fourier Transform Infrared Spectroscopy, X-ray diffraction analysis and thermal analysis. Further, the various pharmacotechnical properties of the calcium lactate obtained from mussel shells were determined in comparison with an industrial used direct compressible Calcium lactate DC (PURACAL®). The obtained results suggest that mussel shell by-products are suitable for the development of chemical compounds with potential applications in the pharmaceutical domain.
Highlights
Introduction iationsThe huge growing demand for renewable feedstocks makes marine byproducts one of the most attractive research areas
The present study developed a way to capitalize on calcium from mussel shells in the Mytilus galloprovincialis and Mytilus edulis are found in abundance in the Black Sea
The elemental analysis indicates that the obtained powder contains a higher amount of calcium lactate with small quantities of calcium nitrate
Summary
Elemental composition composition of of calcium calcium lactate lactate and and calcium calcium nitrate. 2. Elemental composition of calcium lactate and calcium nitrate. 3. FTIR spectra of synthesized calcium lactate (red line) and standard calcium lactate line). The small band observed at 1698.0 cm−1 is produced by the small content of calcium nitrate from the composition of the newly synthesized calcium lactate. This band is not visible in the spectrum of the standard calcium lactate. XRD analysis presence of calcium nitrate may be due to its small quantity in the prepared sample.
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