Abstract
Development of high performance liquid chromatographic method for determination of famotidine and ranitidine.HCl in pharmaceutical preparations
Highlights
The description of selective histamine H2 - receptor by Black in 1970 was landmark in the history of pharmacology and set the stage for the modern approach to the treatment of acid - peptic disease, which until had relied almost entirely on acid neutralization in the lumen of the stomach(Goodman & Gilmans,2001).Famotidine and ranitidine -HCl are histamine H2 receptor antagonists, that potently inhibits gastric acid secretion and commonly used in treatment and prevention of gastric and duodenal ulcers(Langtry et al,1989)
The success of the HPLC method depends on a good selection of number of factors such as: type, concentration and pH of mobile phase, flow rate, temperature and column dimensions(Otles & Hisil,1993), which were applied in this paper for the simultaneous determination of famotidine and ranitidine in pharmaceutical preparations using a developed HPLC system by optimizing parameters that affecting the separation
All reagents used were of analytical grade except acetonitrile and methanol, which were HPLC grade
Summary
The description of selective histamine H2 - receptor by Black in 1970 was landmark in the history of pharmacology and set the stage for the modern approach to the treatment of acid - peptic disease, which until had relied almost entirely on acid neutralization in the lumen of the stomach(Goodman & Gilmans,2001).Famotidine and ranitidine -HCl are histamine H2 receptor antagonists , that potently inhibits gastric acid secretion and commonly used in treatment and prevention of gastric and duodenal ulcers(Langtry et al ,1989). (Delgado et al, 1985),capillary electrophoresis(Marine et al.,2002), chemiluminescence (Barnett et al.,1999) ,flow injection analysis FIA(Lopez-Erroz et al.,1996), and high performance liquid chromatographic(HPLC)(Huang et al, 1999,Ficarra et al.,1987 and Biffar et al.,1986)methods. A number of famosam tablets were grinded to fine powders ,sieved and 100mg portion of the powder ,equivalent to the average weight of 20 tablets ,was dissoved in about 100ml (mobile phase solution). Histac tablet (Ranbaxy labratories limited): Each tablet contains 150mg ranitidine -HCl. A number of tablets were grined into fine powder, sieved and a portion of the powder (150mg),equivalent to the average weight of 20 tablets,was dissolved in 50ml (methanol).The solution was vigorously shaked for 30min, filtered and 1ml of the filterate was diluted to 50ml with methanol. A sample injector was 6CE model;with 20ml Injection loop
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