Abstract
Early abortion is one of the most common complications during pregnancy. However, the frequent handling of the genital region, more precisely the vagina, which causes discomfort to patients in this abortion process due to the frequency of drug insertion, as four pills are inserted every six hours, has led to the search for alternatives to alleviate the suffering caused by this practice in patients who are already in a shaken emotional state. Hence, this work aimed to develop composites of gelatin and misoprostol, using a conventional single-dose drug delivery system. These composites were prepared by freeze/lyophilization technique, by dissolving the gelatin in distilled water, with a concentration of 2.5% (w/v), and misoprostol was incorporated into the gelatin solution at the therapeutic concentration (800 mcg). They were subsequently molded, frozen and lyophilized. The samples of the composites were then crosslinked with sodium tripolyphosphate (TPP) 1% (v/v) with respect to the gelatin mass for 5 min. The characterization techniques used were: Optical Microscopy (OM), Fourier Transformed Infrared Spectroscopy (FTIR), Thermogravimetry (TG), Swelling, Biodegradation and Cytotoxicity. In OM it was observed that the addition of the drug improved the cylindrical appearance of the compounds, in comparison with the sample that was composed of only gelatin. There was a reduction in the degree of swelling with the addition of the drug and crosslinking. The cytotoxicity test indicated the biocompatibility of the material. Based on the results obtained in these tests, the composites have therapeutic potential for uterine emptying in pregnancy failures, especially in the first trimester.
Highlights
Throughout the twentieth century, supported by the discovery of the contraceptive pill and by the separation between reproduction and pleasure, women’s right to reproductive and sexual health gained space, and several changes were observed due to feminist movements and claims by social groups [1]
The results of Optical Microscopy (OM) indicate that addition of misoprostol positively influenced the shape and appearance of the biomaterial; in addition, the crosslinking process with TPP promoted a retraction in the samples after the second lyophilization cycle
Fourier Transformed Infrared Spectroscopy (FTIR) spectra of the material with and without crosslinking with TPP showed the incorporation of the drug in the gelatin matrix
Summary
Throughout the twentieth century, supported by the discovery of the contraceptive pill and by the separation between reproduction and pleasure, women’s right to reproductive and sexual health gained space, and several changes were observed due to feminist movements and claims by social groups [1]. Are mostly used with safety to remedy cases of pregnancy termination are RU 486 and misoprostol. Daily practice shows that the fact that the protocol indicates the use of 800 μg of this drug in pregnancy failures, and that current presentations do not exceed 200 μg, causes situations that present greater discomfort to patients who need this drug. This discomfort is often related to edema of the vulva, local pain, erythema, asthenia, and anxiety caused by both excessive handling and length of stay. To facilitate administration and offer more comfort to women, misoprostol can be added to biodegradable and biocompatible components, such as gelatin, to obtain a biocomposite
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