Abstract
Recent advances in chemistry-based engineering have developed smart nanodevices for realizing targeted therapy by rationally integrating versatile molecular technologies to achieve specific structures and functionalities. Gene therapy is one of the most intriguing targets, because nanodevices to deliver fragile DNA into pathological cells and exert effective transgene expression are indispensable for achieving this innovative therapeutic modality. The largest challenge lies in the development of an appropriate systemic delivery system that can withstand the harsh environment of circulating blood and efficiently accumulate in a targeted location for gene expression. This review focuses mainly on our polymer-based DNA delivery systems, which are fabricated from polyion complexation between plasmid DNA and functionalized poly(ethylene glycol)-based block catiomers, and highlights their development to systemic settings for application to cancer treatment. Smart polyplex micelles for systemic gene therapy fabricated by rationally integrating versatile molecular-based technologies. The polyplex micelles, which are formed through an electrostatic interaction-mediated self-assembly process of functional block copolymers and plasmid DNA, assume a task to transport therapeutic gene into nucleus of pathological cells via systemic route for functional protein expression.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
