Development of electrochemical noninvasive glucose nanobiosensor using antioxidants as a novel mediator

Abstract

AbstractDiabetes mellitus is a chronic disease, and millions of people die from its related disorders each year; thus, people with diabetes have to control the level of blood glucose frequently. In the last decade, the noninvasive biosensors have been considered to track glucose level without finger pricking. In this research, the glucose biosensor was developed using a new formulation containing hydroxylmethoxyphenyl derivation as a novel mediator that was extracted from a natural source. The mediator characterization was performed by means of thin‐layer chromatography and Fourier transform infrared spectroscopy, and the electrochemical activity of the prepared biosensor was evaluated by Autolab potentiostate machine. Scanning electron microscope micrographs revealed a flat surface on the modified electrode that is crucial in electron conduction equivalence. The cyclic voltammetry examination ascertained the irreversible oxidative reaction of phenolic mediator that leads the biosensor system to more electron formation. The obtained results demonstrated that antioxidants could improve the electron forming and also it could enhance the current signal. Finally, response time could be controlled by variation in polyvinyl alcohol concentration.