Abstract
A major emphasis in systems biology is to unfold the dynamic network properties of complex biological processes through modeling and simulation utilizing various experimental data. CIDMS was developed to provide an integrated bioinformatics platform for systems biology approach studying mammalian cardiac systems. CIDMS has following information which was manually curated from published literatures and public databases: 1) list of genes, proteins, pathways critical for development and functioning of heart; 2) list of human cardiac diseases; and 3) mathematical / computational models employed to study cardiac biological processes and diseases. These lists are supplemented with key annotations like function, regulatory mechanisms, interactions and references to the source of information in context of cardiology. CIDMS also provides a large amount of additional automated data integrated within the framework of manually curated data. Data such as structure, function, domains, location, phenotype, molecular interactions, and pathways from numerous life-science databases are made available. In addition to these qualitative data, CIDMS integrates quantitative data such as reaction kinetics, stoichiometric and model information. This broad data integration has become possible by the state of the art technologies like data-warehouse and through webservices (SOAP interfaces) of well established public database servers ensuring up to the minute information. The comprehensive information can be easily searched and browsed by categories and ontologies with an advanced web interface hosted at http://cidms.org.
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