Abstract
Compared to inorganic carriers, Biodegradable Porous Starch Foam has shown strong properties and has a nano-porous structure, low density and large specific surface area and pore volume of Biodegradable Porous Starch Foam to improve the solubility and enhance absorption of poorly water-soluble drugs. The study aimed to prepare Biodegradable Porous Starch Foam used to improve bioavailability of poorly water-soluble drug Eprosartan Mesylate. The solid-state properties of the loaded BPSF samples have been characterised by SEM, FTIR, XRPD, and DSC for the analysis of the state of dispersion of loaded eprosartan mesylate compared with the pure eprosartan mesylate. By solvent immersion/ evaporation, the eprosartan mesylate is absorbed by a porous structure. The SEM shows the drug is loaded with crystals and rod-shaped pores. In XRPD, crystallinity of BPSF and unprocessed starch is measured as 26.76 percent and 28.6 percent, respectively. Eprosartan mesylate is thus identified on the surface of BPSF only by FTIR. From the in vitro drug release studies, it was confirmed that BPSF can be used to enhance the water solubility of poorly water-soluble drugs. This study demonstrates the great significance of using BPSF as a new delivery mechanism for medicines that are poorly water-soluble based on these results. This method can be used as a replacement for another currently used technique to enhance the stability of poorly soluble drugs.
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