Abstract
Background and Aims : We have studied changes in the accumulation of protoporphyrin IX (PpIX) induced by exposure to 5-aminolevulinic acid (5-ALA). Cytoplasmic hybrids were the object. PpIX, a widely used photosensitizer in clinical practice, is produced by 5-ALA in mitochondria in the heme synthesis reaction cascade. With an increased intake of 5-ALA from the outside, excess PpIX accumulates in cells at an increased concentration. The accumulation of PpIX depends on the metabolic activity of the mitochondria in cells.
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