Abstract
Abstract Three-week-old weanling male Syrian golden hamsters were inoculated i.v. with 108.5 TCID50 of oncogenic DNA simian virus 40 (SV40). All input virus was cleared from the blood stream within 48 hr. Antibody to SV40 V (virion) antigen appeared as early as the 1st postinoculation week, reached a peak by the 3rd week, and gradually decreased thereafter. Antibody to SV40 T (tumor) antigen was first detected by the 4th week. Its appearance preceded tumor induction by as many as 6 weeks for a tumor at the in situ stage, and 10 weeks for a palpable tumor. The results indicate that the development of antibody to viral and tumor antigens in hamsters inoculated i.v. at 3 weeks of age with high titer SV40 precedes rather than coincides with or follows the induction of tumors. The presence, therefore, of these antibodies in the serum of hosts in which the virus-cell interaction is of the transforming type, only signifies prior virus exposure, and can not be taken as evidence for the establishment of tumors in vivo.
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