Development of an International Canine Spinal Cord Injury observational registry: a collaborative data-sharing network to optimize translational studies of SCI.

Abstract

Study DesignProspective cross sectional cohort studyObjectivesThe canine spontaneous model of spinal cord injury (SCI) is as an important pre-clinical platform as it recapitulates key facets of human injury in a naturally occurring context. The establishment of an observational canine SCI registry constitutes a key step in performing epidemiologic studies and assessing the impact of therapeutic strategies to enhance translational research. Further, accumulating information on dogs with SCI may contribute to current “big data” approaches to enhance understanding of the disease using heterogeneous multi-institutional, multi-species data sets from both pre-clinical and human studies.SettingMultiple veterinary academic institutions across the United States and Europe.MethodsCommon data elements recommended for experimental and human SCI studies were reviewed and adapted for use in a web-based registry, to which all dogs presenting to member veterinary tertiary care facilities were prospectively entered over approximately one year.ResultsAnalysis of data accumulated during the first year of the registry suggests that 16% of dogs with SCI present with severe, sensorimotor complete, injury and that 15% of cases are seen by a tertiary care facility within 8 hours of injury. Similar to the human SCI population, 34% were either overweight or obese.ConclusionsSeverity of injury and timing of presentation suggests that neuroprotective studies using the canine clinical model could be conducted efficiently using a multi-institutional approach. Additionally, pet dogs with SCI experience similar comorbidities to people with SCI, in particular obesity, and could serve as an important model to evaluate the effects of this condition.