Abstract
Hypochlorous acid (HOCl) plays a crucial role in the immune defence against invasive bacteria and other biological processes in living organisms. A turn-on fluorescent probe (PZ-HA) for sensitive detection of HOCl was developed. After the addition of HOCl, an approximately 80-fold enhancement in fluorescence intensity at 605nm was observed. PZ-HA has a large Stokes shifts that can effectively avoid the self-absorption of the fluorescence. In addition, PZ-HA has excellent properties, including fast responsive, good selectivity and low cytotoxicity and well membrane-permeability. The potential of the probe as biosensor for HOCl was demonstrated by imaging of exogenous and endogenous HOCl in living cells. Further, the probe was applied to the fluorescence imaging of HOCl in zebrafish. Therefore the probe is expected to be useful for the accurate detection of HOCl in complex biosystems.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
