Abstract
We devised a new method of xenogeneic direct hemoperfusion of a bioartificial liver support, which consists of a leukocyte adsorbent column, an immunoglobulin adsorbent column, and a substitute unit for hepatic function. Using this method in a hybrid bioartificial liver system incorporated with a nonwoven fabric bioreactor containing porcine hepatocytes, we successfully performed xenogeneic direct hemoperfusion in a canine liver failure model for 3 h without hyperacute rejection. Adequate ammonia detoxification was exhibited, and no findings of hepatocyte destruction by leukocytes or immunological proteins were detected in the canine blood analysis. Beneficial effects were also detected in a significant increase in Fischer's ratio and a decrease in intracranial pressure, indicating that our system could contribute to recovery from hepatic coma in patients with severe liver failure.
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