Abstract
The development of a facility for irradiation of murine and primate tissue presents several challenges. First, extremely low fluences (106–1011 ions cm−2) are required to deliver doses of 1 mGy–50 Gy using MeV proton. Second, the tissues, particularly from non-human primate, may be infectious to humans. Third, protection of irradiated tissue samples from contamination by mold and bacteria is critical. Here we present an ultra-low flux irradiation facility and associated fluence control for biological cell and tissue irradiation under sterile biosafety level-2 conditions suitable for use with low energy (1–3.4 MeV) protons. The operation is demonstrated using murine astrocytes.
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