Abstract
Less local availability and higher skin permeation restrict wide application of silver sulfadiazine (SSD) formulations against infectious burn wound. We aimed to develop β-cyclodextrin inclusion complex-based in situ pluronic gel of SSD (β-CD-ssd P-Gel). Formation of inclusion complex was confirmed by FT-IR, DSC, SEM, and XRD and checked for improved solubility. Poloxamer (407/118)-based in situ gel of inclusion complex was prepared and characterized for its gelation temperature (33.50 °C), viscosity (1159.25 ± 5.60 cps), pH (6.4 ± 0.56), and drug content (91.56 ± 1.62%). The developed gel showed slow drug release and slow permeation of the drug through the skin. It showed broader zone of Staphylococcus aureus growth inhibition (31 ± 0.20 mm) and high wound contraction (98.89%) when compared with the marketed formulation (26 ± 0.20 mm and 58.00%, respectively). A consistent, biocompatible, β-CD-ssd P-Gel was prepared successfully. It was found able to ensure increased local availability by forming viscous gel below body temperature, high SSD availability at the desired site, and high efficacy against infectious wound.
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