Abstract
Non-biodegradable materials with a low swelling capacity and which are opaque and occlusive are the main problems associated with the clinical performance of some commercially available wound dressings. In this work, a novel biodegradable wound dressing was developed by means of alginate membrane and polycaprolactone nanoparticles loaded with curcumin for potential use in wound healing. Curcumin was employed as a model drug due to its important properties in wound healing, including antimicrobial, antifungal, and anti-inflammatory effects. To determine the potential use of wound dressing, in vitro, ex vivo, and in vivo studies were carried out. The novel membrane exhibited the diverse functional characteristics required to perform as a substitute for synthetic skin, such as a high capacity for swelling and adherence to the skin, evidence of pores to regulate the loss of transepidermal water, transparency for monitoring the wound, and drug-controlled release by the incorporation of nanoparticles. The incorporation of the nanocarriers aids the drug in permeating into different skin layers, solving the solubility problems of curcumin. The clinical application of this system would cover extensive areas of mixed first- and second-degree wounds, without the need for removal, thus decreasing the patient’s discomfort and the risk of altering the formation of the new epithelium.
Highlights
Human skin exerts a pivotal function as a protection barrier against diverse exogenous noxious factors; it is exposed and undergoes diverse types of injuries, including burns, ulcers, trauma, lacerations, and acute or chronic wounds, which may compromise its integrity [1].In this regard, when skin is damaged, a specialized and highly regulated dynamic process immediately takes place: wound healing [2]
Zeta potential is commonly employed to measure the charge in the nanoparticles and/or electrostatic repulsion [1], and the literature indicates that nanoparticles are stable in suspension with a zeta potential above ±30 mV [23]
Despite the curcumin and stabilized with Pluronic® F-68 (CNp) zeta potential value not being in this range, it should be considered that Pluronic® F-68 was added as a stabilizer of nanoparticles, which provides them with stability by means of a repulsion effect through a steric mechanism [24]
Summary
Human skin exerts a pivotal function as a protection barrier against diverse exogenous noxious factors; it is exposed and undergoes diverse types of injuries, including burns, ulcers, trauma, lacerations, and acute or chronic wounds, which may compromise its integrity [1]. In this regard, when skin is damaged, a specialized and highly regulated dynamic process immediately takes place: wound healing [2]. Several dressings may adhere to the wound and require constant changes, which may interfere with the granulation process and delay the healing course
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