Abstract
Transdermal drug delivery system (TDDs) is novel specified dosage forms, when drug deliver through the skin at controlled rate to the systemic circulation as applied to the intact skin. The present investigation is to prepared transdermal films of trandolapril intended for controlled release polymeric transdermal patch for a care of cardiac patients. The objective of current work is to develop the polymeric transdermal patch for immediate release of drug materials. The transdermal film of trandolapril was prepared by using various combinations of the polymers with solvent evaporation technique. The proposed formulations have a number of variables i.e. plasticizers, penetration enhancers, rate controlling process and adhesion on skin. We may apply biologically active permeation enhancers i.e. Isopropyl myristate, Propylene glycol and Mineral oils etc. The result concluded that polymers chitosan have hydrophilic nature and able to enhance spreadability and dispersibility of the water soluble trandolapril enhanced drug release more than 95.5% within a 6 - 7 h as needed for immediate release. The all evaluation parameters and in-vitro drug release study was used for selection of best polymeric film prepared with chitosan (2%) and PVP (1%) as plasticizer for the preparation of single layered transdermal film as first immediate release layer.
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