Abstract
A physiologically based toxicokinetic model typically represents the uptake of a toxicant by a laboratory animal, its distribution to various organs, its metabolic activation and/or detoxication, and elimination of the parent compound and its metabolites. The aim is to predict the dose response of the actual toxic agent (parent compound or metabolite) in the tissue that ultimately develops symptoms of toxicity. In many cases, a subsequent response stimulated by the toxic agent may be mechanistically related to the ultimate health outcome and can serve as an indicator of the effects of the administered chemical. A model can quantify this response as a function of dose, permitting it to be used as a dose surrogate in estimating the toxicant`s effects at low exposures. Because toxicokinetic modeling incorporates a large amount of information about the animal beyond the observation of the incidence of the endpoint at various doses, it offers a method of reducing the uncertainties in risk assessments based solely on external exposure.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
