Developing an evidence-based intervention targeting high-risk migrant workers

Abstract

s / Drug and Alcohol Dependence 146 (2015) e34–e117 e99 miosis was more robust (time-matched or derived parameters; r>0.4). Conclusions: The PK/PD relationship for abuse potential is highly variable and is influenced by numerous factors, including dosage form manipulation and ROA. Effects unrelated to opioid exposure impact a subject’s drug experience. PK alone cannot be used to reliably assess abuse deterrence in HAP studies. Financial support: Supported by Altreos Research Partners, Inc. and Purdue Pharma LP. http://dx.doi.org/10.1016/j.drugalcdep.2014.09.635 Developing an evidence-based intervention targeting high-risk migrant workers Roman Shrestha1, Michael Copenhaver2 1 Department of Community Medicine & Health Care, University of Connecticut, Farmington, CT, United States 2 Department of Allied Health & Sciences, University of Connecticut, Storrs, CT, United States Aims: Nepal has a concentrated HIV epidemic and labor migrants share the highest burden. The epidemic among migrant workers has been associated with risky sexual behaviors, and with alcohol and drug abuse. The very few HIV prevention efforts that have been attempted with this group have been unsuccessful primarily due to stigma, discrimination, and insufficient availability of culturally relevant evidence-based interventions (EBIs). In order to address this issue, we propose formative research designed to promote the development of an intervention to reduce HIV transmission risk among migrant workers in Nepal. Methods: As we will describe in the presentation of our intervention development process, wewill use the ADAPT-ITT approach for intervention adaptation which will involve focus groups with themembers of the target population and treatmentproviders –we will refine and adapt the Holistic Health Recovery Program (HHRP) – an evidence-based HIV risk reduction behavioral intervention–to HHRP-N(epal) for optimal use with the high-risk migrant population in Nepal. Interview items will focus on the HIV risk profile of the target population and ways to optimize the intervention content (i.e., specific content areas of the original evidence-based HHRP modules to include/exclude, emphasize/abbreviate), delivery modality (group vs. individual), and duration (length/timing). In order to develop a culturally sensitive intervention, the program will draw upon Wiley’s framework that includes accommodation, incorporation, and adaptation. Together, all of these data will inform intervention adaptation and subsequent pilot testing of the adapted intervention. Conclusions:Weexpect that the formative process described in this presentation will provide the empirical foundation necessary to strongly inform a subsequent extramurally funded study of an adapted EBI targeting high-risk migrant workers in Nepal. Financial Support: None. http://dx.doi.org/10.1016/j.drugalcdep.2014.09.636 Examining the association between methadone maintenance treatment and body mass index Stacey C. Sigmon1, Jennifer Fenn2 1 Psychiatry, University of Vermont, Burlington, VT, United States 2 Nursing, University of Vermont, Burlington, VT,