Abstract
Recent evidence suggests that Alzheimer's Disease (AD) is linked to fungal brain infections. We have previously established an acute model of cerebral mycosis by intravenously injecting the pathogenic yeast Candida albicans. The resulting infection induces mild transient memory deficits and fungal induced glial granulomas consisting of microglia and amyloid β deposits surrounding yeast aggregates. This structure essentially duplicates AD's characteristic senile plaque. AD involves numerous senile plaques and tauopathy that presumably accrue over many years potentially from chronic infection.
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