Abstract
Object: This work explains the theoretical basis of “Hanshi Zufei Decoction” for the treatment of Coronavirus Disease 19 (COVID-19) through Western medical theories. Methods: We analyze the guideline of the “Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia” (Version I to Version VII) made by China, “Clinical Management of Severe Acute Respiratory Infection When Novel Coronavirus (2019-nCoV) Infection is Suspected—Interim Guidance” made by WHO, “Therapeutic Guidelines: Gastroenteropathy Section (Version V of Original)” and “Therapeutic Guidelines: Antibiotics Section (Version XV of Original)” published by Australia, and the origin of classical prescription of “Hanshi Zufei Decoction”: “Shanghan Lun (Treatise on Febrile Diseases)”, “Jinkui Yaolue (Synopsis of Golden Chamber)” and “Wenyi Lun (Treatise on Plague). We search the dictionary of traditional Chinese medicine (Version II) manually. Literature is searched from 2001 to 2020 on the Wiley online library. We conduct a comparative study on the traditional Chinese medicine (TCM) syndromes of “Hanshi Zufei Decoction”, the pathogenesis and clinical manifestations of respiratory system diseases and acute gastrointestinal inflammation by COVID-19. And we conduct the pharmacological inquiry of “Hanshi Zufei Decoction”. Results: The respiratory and gastrointestinal symptoms of COVID-19 and the basis of the “Hanshi Zufei Decoction” are basically considered to be consistent. “Hanshi Zufei Decoction” can relieve respiratory symptoms, protect gastrointestinal mucosa, promote intestinal emptying, and have anti-inflammatory and antibacterial effects in the form of clusters. The dosage form and dosage used are in line with the range of pharmacological activity of the drug. Conclusions: “Hanshi Zufei Decoction” may have a good performance in reducing toxicity and controlling inflammation through intestinal emptying, and may play an active role in the treatment of COVID-19.
Highlights
In more than 4 months of the outbreak of the novel coronavirus, there are confirmed cases in 215 countries and regions around the world, with a total of more than 8 million infections and more than 400,000 deaths
We conduct a comparative study on the traditional Chinese medicine (TCM) syndromes of “Hanshi Zufei Decoction”, the pathogenesis and clinical manifestations of respiratory system diseases and acute gastrointestinal inflammation by COVID-19
“Hanshi Zufei Decoction” is derived from the classic treatise “Wenyi Lun (Treatise on Plague)” which refers to the second edition of “Wenyi Lun (Treatise on Plague)”, published by China pharmaceutical science and technology press, edited by Wu Youxing and proofread by He Yongxiao, and “Wenyi Lun Pingzhu” which is published by people’s medicine publishing house, annotated by Zhejiang institute of traditional Chinese medicine
Summary
In more than 4 months of the outbreak of the novel coronavirus, there are confirmed cases in 215 countries and regions around the world, with a total of more than 8 million infections and more than 400,000 deaths. The author tries to explain the possible value of “Hanshi Zufei Decoction” in the epidemic in an understandable way. The author explains the incomprehensible ancient medical texts of Chinese medicine in plain language and the source of “Hanshi Zufei Decoction” by adding and subtracting the classic prescription “Dayuan Yin (Membrane Source Opening Beverage)”. The author conducts a comparative study on the clinical manifestations and indications of “Hanshi Zufei Decoction” and treatment guidelines, and explores the correlation between them. The author links the treatment methods of “promoting, vomiting, descending and clearing” in “Moyuan Lun (Theory of Membranous Origin)” with the treatment of COVID-19, and tries to explain the effectiveness and scientificity of “Hanshi Zufei Decoction”. The author hopes that this article can bring some help to the treatment of COVID-19
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