Abstract
Objective To develop a rapid analysis method which is applicable for the monitoring of clinical pharmacy Voriconazole's plasma concentration,and to analyze the monitoring results at the same time.Methods We analyzed plasma from HIV-positive people by high performance liquid chromatography (HPLC),using 5 μ m of Agilent Eclipse XDB-C18 column,mobile phase of 1％ isopropyl alcohol:acetonitrile (40∶60),flow rate:1.0 ml/min,wavelength:250 nm,to carry out the recovery rate,linearity and precision tests,and combined with patients' laboratory data,to analyze the significance of blood concentration.Results Within 0.2-19.8 mg · L-1,plasma concentration of Voriconazole standed a good linear relationship(R2=0.9912),recovery rate and precision,showing the specificity of this method.Conclusion Using HPLC to monitor Voriconazole plasma concentration of HIV-positive people is a fast,accurate and efficient analysis method for clinical samples,which can reduce clinical waiting time.Voriconazole plasma concentration monitoring has important clinical value. Key words: Voriconazole; HIV-positive; Plasma concentration monitoring; High performance liquid chromatography
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