Abstract
Purpose: In all types of ischemic stroke, especially in the acute phase, excessive oxidative stress causes structural and functional damage to the brain. This may play a major role in the pathophysiology of the brain damage. Higher serum levels of bilirubin have therapeutic effects in oxidative stress-induced stroke. Nevertheless, role of increased serum levels of bilirubin in the acute phase of ischemic stroke is ccontroversial.Methods: This study was a cross-sectional prospective descriptive study conducted in the Emergency Department (ED) of Imam Reza hospital, Tabriz University of Medical Sciences, Tabriz, Iran, throughout six months. 275 ischemic stroke patients were evaluated based on their brain CT scan infarct size, NIHSS, MRS, and serum levels of bilirubin. Later, data were analyzed using SPSS software.Results: Results: Total, direct and indirect bilirubin levels were significantly higher in expired patients (p < 0.0001). Total (p< 0.0001), direct (p< 0.0001) and indirect (p< 0.0001) bilirubin levels, NIHSS score (p< 0.0001), and ischemic area (p< 0.0001) significantly predicted the outcome in these patients.Conclusion: Total, direct and indirect bilirubin levels was significantly associated with mortality in the acute phase of ischemic stroke patients.
Highlights
Stroke is known as a clinical syndrome with focal neurologic defects which last longer than 24 hours
This study was a cross-sectional prospective descriptive study conducted in the Emergency Department (ED) of Imam Reza hospital, Tabriz University of Medical Sciences, Tabriz, Iran, throughout six months. 275 ischemic stroke patients were evaluated based on their brain CT scan infarct size, National Institutes of Health Stroke Scale (NIHSS), MRS, and serum levels of bilirubin
Total, direct and indirect bilirubin levels was significantly associated with mortality in the acute phase of ischemic stroke patients
Summary
Stroke is known as a clinical syndrome with focal neurologic defects which last longer than 24 hours It is the first cause of disability in both developed and developing countries. Bilirubin is known to be of very potent antioxidant properties.[13] High serum levels of bilirubin have therapeutic effects in diseases caused by oxidative stress.[7] these changes and their role in the acute phase of ischemic stroke are less known.[9] In a study, it has been shown that with an increase in the bilirubin levels, the risk of stroke is reduced; the correlation, was not found to be significant in either hemorrhagic stroke or women patients. In a study by Arsalan et al, high serum bilirubin levels increased the severity of the stroke, the length of
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