Abstract
LA335 and LA337 are two temperature-sensitive mutants of the Prague strain of Rous sarcoma virus (subgroup C) which are unable to initiate infection at the nonpermissive temperature (41°). The virions of LA335 and LA337 are shown to possess a reverse transcriptase activity which is more heat labile than that of the wild type. Genetic studies are described which indicate that the inability of LA335 or LA337 to initiate infection at 41° is due to this temperature-sensitive enzyme. The genetic markers for reverse transcriptase of LA335 and LA337 undergo high-frequency recombinations with markers for host range, and possibly transformation.
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