Determination of the Anti‐HIV Drug Nevirapine Using Electroactive 2D Material Pd@rGO Decorated with MoS2 Quantum Dots

Abstract

AbstractHerein we report the detection of an anti‐HIV drug Nevirapine (NVP) through a sensitive electrochemical method using efficient electro‐active 2D materials; Palladium nanoparticles supported reduced graphene oxide (rGO), i.e., Pd@rGO, MoS2 quantum dots (QDs) and Pd@rGO decorated with MoS2 QDs modified electrodes. We have shown an interaction between Pd@rGO and MoS2 QDs in the composite based on FT‐IR and UV‐Vis. absorption studies. The interaction between Pd@rGO and MoS2 QDs in designed material leads to highly efficient electro‐activity that is actually responsible for the broad spectrum quantification of frequently used anti‐HIV drug Nevirapine. The electrochemical oxidation behaviour of NVP is studied using cyclic voltammetry (CV) over bare glassy carbon electrode and modified electrodes with alone Pd@rGO and MoS2 QDs and finally over designed material Pd@rGO/ MoS2 QDs. The excellent catalytic effect is observed over designed material as evident from oxidation at relatively lower potential of 0.65 V vs. Ag/AgCl and large peak current in comparison with others. Pd@rGO/ MoS2 QDs modified electrode exhibits a linear increase in oxidation peak current with an increase in NVP concentration in the range of 0.1 – 80 μM with limit of detection (LOD) of 50 nM at signal‐to‐noise ratio (S/N): 3. The developed sensing platform shows excellent stability and sensitivity to make it suitable for the determination of NVP in the complex system.