Abstract
Bioanalytical methods for determining the total concentration of the new local anaesthetic drug ropivacaine in blood plasma, urine and tissues are presented. Ropivacaine is a drug mainly used in connection with surgery and for post-operative pain relief. The biological samples were prepared using liquid–liquid extraction and analysed using capillary gas chromatography with nitrogen–phosphorus detection or mass spectrometry. The methods are highly selective and reliable with a between-day precision, given as the relative standard deviation, generally below 6%. More than 20 000 samples have been analysed using the methods described.
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Schedule a callMore From: Journal of Chromatography B: Biomedical Sciences and Applications
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