Abstract
It is described the use of 1,3 dinitrobenzene or 2,4 dinitrophenyl hydrazine is used as coupling agent for the spectrophotometric determination of paracetamol. This method is easy and simple based on the reaction of acid hydrolysis of paracetamol to produce p-aminophenol, which in turn reacts with nitrite in acidic standard to form diazonium ion, which is coupled with coupling agent in basic standard to produce azo dyes. The formed dyes follow Beer’s law in the range of 0.8-20.5 mg mL-1 of paracetamol with 1, 3 dinitrobenzene or 0.5-18.4 mg mL-1 of paracetamol with 2,4 dinitrophenyl hydrazine with absorption maxima at 429 nm or 430 nm. The molar absorptivity and Sandell’s sensitivity of paracetamol with 1,3 dinitrobenzene or paracetamol with 2,4 dinitrophenyl hydrazine azo dyes were 1.965×104 L mol-1 cm-1 or 2.776×104 L mol-1 cm-1, and 7.692×10-3 mg cm-2 or 5.698×10-3 mg cm-3 respectively. The dyes formed are stable for more than 12 h. The optimal reaction circumstances and other analytical parameters are evaluated. Interference due to foreign organic compounds have been studied. The method has been effectively applied to the determination of paracetamol in pharmaceutical samples.
Highlights
Paracetamol called acetaminophen or 4acetamidophenol, is a common pain reliever and fever reduction medicine[1]
The absorption spectra of the azo dye produced between paracetamol-1,3 dinitrobenzene or [2,4] dinitrophenyl hydrazine is presented in Fig. 1 having absorption maximum at 429 nm or 430 nm, respectively
The formed dyes obeys Beer’s law in the range of 0.8-20.5 g mL-1 of paracetamol with [1,3] dinitrobenzene or 0.5-18.4 g mL-1 of paracetamol with [2,4] dinitrophenyl hydrazine and the reaction method is shown in Scheme 1
Summary
Paracetamol called acetaminophen or 4acetamidophenol, is a common pain reliever and fever reduction medicine[1]. Paracetamol was first prepared in 1878 by Harmon Northrop Morse an American chemist[2]. It is available as a generic medication with trade names including Tylenol and Panadol, among others[3]. It is often sold in the commercial markets with a major ingredient in many cold and flu remedial combination drugs. It is usually used either by mouth or rectally, but is available intravenously[1,4]. Paracetamol is accessible in as a tablet, drops, capsules, injection, and syrup[5]
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