Abstract
A procedure is described for the simultaneous determination of oxpentifylline and three metabolites in plasma by capillary gas chromatography. Plasma samples are acidified and extracted with chloroform. The carboxylic acid compounds are converted to their methyl esters and the hydroxylated metabolites to their O-trifluoroacetates prior to analysis by capillary gas chromatography using nitrogen-selective detection. The detection limits for the compounds are 5 ng/ml and the assay has been applied to the analysis of plasma from volunteer trials after oral administration of oxpentifylline.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Chromatography B: Biomedical Sciences and Applications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
