Abstract
The renal lithium clearance can be used as a measure of the flow of water that is delivered from the proximal tubules to the more distal parts of the nephron. This study examines in rats whether V/C Li, the urine flow divided by lithium clearance, ,can be used as a specific measure of the degree of inhibition of distal water reabsorption. V/C Li rose in response to inhibition of distal water reabsorption produced by treatment with lithium. It remained unaffected by variations in glomerular filtration rate produced by removal of one kidney; it also remained unaffected by an increase of the fractional proximal reabsorption of water produced by treatment with thiazide. V/C Li is therefore a specific measure of the inhibition of distal water reabsorption. V/C Li is equal to S Li/ U Li, the lithium concentration in serum divided by the lithium concentration in urine. Since the urine flow does not enter this expression, the variable V/C Li can be determined without quantitative collection of urine. This makes the use of V/C Li well suited for clinical assessment of the degree of lithium-induced impairment of distal water reabsorption.
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