Abstract
Dodonaea viscosa L.Jacq. is an evergreen shrub and native to Asia, Africa, and Australia. It has been used as traditional medicine in different countries. The foremost objective of the current study was to discover the protective potential of D. viscosa flowers Methanol (DVM) and Chloroform (DVC) extracts against CCL4 induced toxicity in mice. This study was intended to identify phytochemicals through HPLC, GCMS, and FT-IR, as well as in vitro antioxidant and in vitro anti-tuberculosis activity. Our comprehensive findings indicate that Dodonaea viscosa is valuable and widespread herbal medicine through therapeutic potentials for curing various ailments. Dodonaeaviscosa flowersare found to have a protective effect against oxidative stress produced by CCL4 in the liver, kidney, and spleen. The intake of DV extracts restored the level of hepatic enzymes (ALP, AST ALT, and Direct bilirubin), hematological parameters (RBCs, WBCs, and Platelets), total protein, and liver antioxidant enzymes (SOD, GPx, and CAT) after a decline in levels by CCL4. Histopathological results discovered the defensive effect of 300 mg/kg of DVM extract against CCL4 induced damage, thus having an improved protective effect compared to DVC and control. As a result of metabolite screening, the total flavonoids and total phenolics were present in abundance. A phytochemical investigation by HPLC identified gallic acid, epicatechin, cumeric acid, flavonoids, while GCMS estimated oleic acid (Octadecenoic acid) (C18H34O2), Stearic acid (C18H36O2), Ricinoleic acid (C18H34O3), and Cedrol (C15H26O). DVM extract exhibited resistance against in vitro Mycobacterium tuberculosis strains. So this study proposed that the protective effect of DV against oxidative damage induced in the liver, kidney, and spleen can be correlated to the antioxidant compounds.
Highlights
Dodonaea viscosa L.Jacq. is an evergreen shrub and native to Asia, Africa, and Australia
Kidney, spleen, and many o thers[5,6] and facilitate damage to the biological molecule and oxidize most of them7. CCL4 has been used in a mouse model for chemically induced hepatotoxicity as a result of oxidative stress
The foremost objective of this study was to discover the protective potential of D. viscosa flowers Methanol (DVM) and Chloroform (DVC) extracts against C CL4 induced toxicity in mice
Summary
Dodonaea viscosa L.Jacq. is an evergreen shrub and native to Asia, Africa, and Australia. The foremost objective of the current study was to discover the protective potential of D. viscosa flowers Methanol (DVM) and Chloroform (DVC) extracts against CCL4 induced toxicity in mice. This study proposed that the protective effect of DV against oxidative damage induced in the liver, kidney, and spleen can be correlated to the antioxidant compounds. There is no detailedstudy reported regarding protective effects of flowers of DV, so taking it into accountpresent study was conducted to validate the potential of therapeutic activity of DV against liver and other organ toxicity. The foremost objective of this study was to discover the protective potential of D. viscosa flowers Methanol (DVM) and Chloroform (DVC) extracts against C CL4 induced toxicity in mice. This study was intended to identify phytochemicals by using HPLC, GCMS, and FT-IR as well as antioxidantand anti-tuberculosis activities
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