Abstract
Objective To observe the effect of fluorine (F) and aluminum (Al) on serum, bone, teeth, brain, kidney and liver tissues, contents of F and Al in different tissues of rats with combined F-Al toxicosis caused by drinking brick tea were determined. Methods Forty SPF grade Wistar rats of 4 weeks, including 24 females and 16 males, weighing between 40 and 50 g, were divided into control group, F group, Al group and brick tea group by random number table according to their weight, ten rats (6 females, 4 males) in each group. The control group received daily drinking water. The F group drank a solution with an F content of 100 mg/L, and the Al group drank a solution with an Al content of 159 mg/L. According to the drinking habits and consumption of the herdsmen, the tea concentration and tea consumption of the rats were calculated for the brick tea group, and a tea soup was made according to the ratio, with the F content of (100 ± 2) mg/L and the Al content of (159.0 ± 1.5) mg/L. One year later, the rats were killed to determine the contents of F and Al in serum, bone, teeth, brain, kidney and liver. Results The contents of F in bone, teeth and liver of the brick tea group [(275.81 ± 55.89), (283.32 ± 70.67), (15.52 ± 7.57) μg/g] were significantly higher than those of the control group [(0.04 ± 0.01), (128.52 ± 12.81), (5.89 ± 0.33) μg/g, P < 0.01]. The Al contents of teeth and liver in the brick tea group [(6.14 ± 1.69), (8.97 ± 0.85) μg/g] were significantly higher than those of the control group [(0.72 ± 0.54), (5.47 ± 0.83) μg/g, P < 0.01]. Conclusions F-Al combined toxicosis caused by drinking brick tea can cause the increases of F contents in bone, teeth and liver, and the increases of Al contents in teeth and liver. The main tissues damaged by F-Al combined toxicosis caused by drinking brick tea in rats are bone, teeth and liver. Key words: Rats; Fluorine; Aluminum; Brick tea
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