Abstract
The dissociation constants of eight antifungal drugs (fenticonazole, isoconazole, itraconazole, ketoconazole, miconazole, ornidazole, tinidazole, tioconazole) have been determined in water and acetonitrile–water binary mixtures by two different methods. Different organic percentages of acetonitrile have been used. For the LC studies 62.5, 65.0 % and 70.0 (v/v) acetonitrile–water binary mixtures were used while spectroscopic measurements were done in water, 10.0 and 20.0 % (v/v) acetonitrile–water. The influence of acetonitrile on the dissociation constants was investigated.
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