Abstract
Bromazepam, in the form of the ion-pair (bromazepam) 3 Cu(ClO 4) 2, can be extracted into methyl isobutyl ketone, and determined indirectly by atomic-absorption spectrometry with a limit of detection of 0.1 μg/ml bromazepam at the 324.8 nm copper resonance line. The optimum conditions for determining this drug (0.4–4.0 μg/ml) are described. The relative standard deviation achieved is 1.7%. The method is selective and free from the interference of other 1,4-benzodiazepines. It was applied to the determination of bromazepam in pharmaceuticals and was also spiked in plasma samples.
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