Abstract
ABSTRACTIn this paper, we examined the effect of adsorbed monovalent ions on the surface charge of liposomal membranes formed from neutral (sphingomyelin), anionic (phosphatidylinositol) lipids mixed in various ratios. The surface charge density of the membrane was determined from electrophoretic mobility measurements at various pHs of solution. A four-quilibria model describing adsorption of ions on the sphingomyelin (SM) membrane and a two-equilibria model describing adsorption of ions on the phosphatidylinositol (PI) membrane was presented. We proposed a mathematical model for characterizing these equilibria. Using these models, together with experimental data of the membrane surface charge density, we determined association constants characterizing the equilibria. The correctness of the proposed model was proven by comparing the theoretical charge variation curves for SM and PI membranes with the experimental date.
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