Abstract
Detection of the Viral Infectious Diseases in Blood by Surface-Enhanced Raman Spectroscopy: Mini Review
Highlights
Raman spectroscopy is an optical spectroscopic technique that is commonly used to identify the vibrational modes of a substance
Studies have shown that metal nanoparticles can dramatically enhance Raman scattering via a nanoparticles-based localized plasmon resonance (LSPR)
By principal component analysis (PCA) a closely related strain of influenza can be differentiated with 103 PFU/ mL and further, by hierarchical cluster analysis (HCA), a single gene deletion can be detected [6]
Summary
Raman spectroscopy is an optical spectroscopic technique that is commonly used to identify the vibrational modes of a substance. Studies have shown that metal nanoparticles can dramatically enhance Raman scattering via a nanoparticles-based localized plasmon resonance (LSPR) This enhancement of the Raman signal enables detection down to the single molecule level (~picomolar) [1,2]. Surface-enhanced Raman spectroscopy (SERS) is a technique which induces local surface plasmons at the vicinity of a metal or dielectric material by laser excitation to enhance the Raman signal. This surface-based detection technique can enhance the Raman signal up to 1010 by molecular adsorption on a rough metal surface and makes single biomolecular detection possible if the target molecule is near the metal surface [3,4]. We will focus on reviewing SERS based detection for different infectious diseases
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