Abstract
Bovine papilomavírus (BPVs) is the etiological agent of bovine papillomatosis, a disease that triggers warts throughout the skin, udder, roofs, genitalia and in more severe cases can develop extensive papillomas, cause neoplasia in the digestive tract and bladder, cause losses in productivity and losses to livestock. In Brazil, the occurrence of BPV infection is relatively common, but the identification of viral types is still sporadic. The present study is a research report that aimed to describe the occurrence of BPV infections in dairy cattle affected by papillomatosis, based on the nucleotide sequences of the ORF L1, the most conserved sequence. Twenty-five samples of cutaneous wart from nine cattle clinically diagnosed as cutaneous papillomatosis were analyzed in the state of Goiás, central-western Brazil. Amplification was obtained in 11 samples (papilloma) from different cattle. PCR reactions followed by sequencing revealed the presence of BPV-1 in 60%, BPV-5 in 40%, and BPV-14 in 20% of the samples analyzed. The presence of coinfection was verified in 60% of the amplified samples. These data suggest that several types of BPV can infect a lesion simultaneously and demonstrate the possibility that BPV infection in epithelial tissue can occur without restriction to one or two viral types, demonstrating the region's genetic diversity. As far as we know, this is the first registry of typification of BPVs of the central-western region of Brazil. This analysis provides important information for bovine papillomavirus (BPV) research in Brazil.
Highlights
Papillomatosis is an infectious disease which has the etiologic agent papilloma virus (PV), characterized by the presence of hyperproliferative lesions, which can progress to malignancy (Daudt et al, 2018)
The present study aimed to identify Bovine papilomavírus (BPVs) found in cattle herds in the State of Goiás - Brazil, this study represents the first case of BPV 14 in the State of Goiás, aiming to contribute to the knowledge of the diversity of PVs that affect the animals and to the generation of effective prophylactic or therapeutic vaccines
BPV-1 was found in lesions on the dewlap, neck, and udder; BPV-5 was detected in lesions on the back and udder; BPV-9 was found on the back; BPV-10, 13 and 14 were found in the neck. and, BPV-12 was detected on the back and udder
Summary
Papillomatosis is an infectious disease which has the etiologic agent papilloma virus (PV), characterized by the presence of hyperproliferative lesions (papillomas), which can progress to malignancy (Daudt et al, 2018). The bovine papilloma virus (BPV) is disseminated in the herd and to date, there is no vaccine or truly effective treatment against the etiological agent (Módolo et al, 2017). Still, it promotes significant losses in the herd, generating economic loss for the producer and the meat, milk and leather industries (Módolo et al, 2017). The only ones known to promote interspecies cross infection are the Deltapapillomaviruses, which raises the question of how this viral type can overcome the interspecies barriers (Roperto et al, 2018)
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