Abstract
A case of multiple keratoacanthoma involving the skin and mucous membranes is reported. An antisquamous antibody was detected in the patient's serum which bound to a membrane antigen on squamous tumor cell lines COLO-16 and SCaBER. The approximate molecular weight of the antigen is 68,000. The antibody appears to be of the IgG class. It is possible that antibodies such as these may be directed toward neoplastic tissue and could play an important role in spontaneous tumor regression seen in patients with multiple keratoacanthoma.
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