Abstract

Previous work in our laboratory has shown that an IV-administered emulsion of perfluorooctylbromide, an agent known to localize in functioning macrophages in the reticuloendothelial system, can be detected in the liver and spleen by using fluorine-19 (19F) MR imaging. In mice that have received a single radiation dose of 1300 rad (13 Gy) (250 kVp) to the abdomen, relatively diminished uptake of perfluorooctylbromide emulsion in the spleen is seen as few as 12 days after irradiation when using 19F MR. When a GE NMR CSI 2-T spectroscopy/imaging system was used, 19F MR images were obtained in 2-16 min, and the postirradiation changes in the spleen were shown. This approach is the first that allows detection of acute postirradiation damage in the spleen in as few as 12 days and potentially allows assessment of macrophage dysfunction in vivo.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.