Abstract
To assess differences in serum proteins in esophageal squamous cell carcinoma patients. 144 esophageal squamous cell carcinoma patients and 50 healthy volunteers were included in this study, with surface-enhanced laser desorption-ionization time-of-flight mass spectrometry and weak cation exchange magnetic beads. Follow-up allowed the relations between serum proteins and prognosis to be analyzed. A total of 93 protein peaks were detected (molecular weight range: 1500-3000), 10 demonstrating statistically significant differences. There were no differences in protein peaks between 92 patients with a survival more than 2 years and 52 patients with survival less than 2 years. There were two significantly different protein peaks between 45 stage II patients with a survival more than 2 years and 14 stage II patients with survival less than 2 years. There was one significantly different protein peak between 22 stage III patients with a survival more than 2 years and 29 stage III patients with survival less than 2 years. Differences of serum proteins in esophageal squamous cell carcinoma are related to prognosis of patients. The protein fingerprint can be helpful for clinical diagnosis and treatment.
Highlights
Esophageal cancer is a common clinical malignancy
144 esophageal squamous cell carcinoma patients and 50 healthy volunteers were included in this study, with surface-enhanced laser desorption-ionization time-of-flight mass spectrometry and weak cation exchange magnetic beads
Original serum protein fingerprints from 33 patients with esophageal squamous cell carcinoma and 33 healthy control subjects was analyzed by Biomarker Wizard software
Summary
Esophageal cancer is a common clinical malignancy. According to the Cancer Statistic Report from the International Agency for Research on Cancer (IARC), there were 462,000 new cases in 2002 and 386,000 deaths. Objective: To assess differences in serum proteins in esophageal squamous cell carcinoma patients. Methods: 144 esophageal squamous cell carcinoma patients and 50 healthy volunteers were included in this study, with surface-enhanced laser desorption-ionization time-of-flight mass spectrometry and weak cation exchange magnetic beads.
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