Detection and analysis of thyroid-stimulating hormone in women under planned pregnancy in Chongqing

Abstract

Objective To screen thyroid function among planned pregnant women in Chongqing, to guide prenatal and postnatal care. Methods Proportional multi-stage stratified cluster random sampling method was adopted to enroll 11 953 planned pregnant women for questionnaire, physical examination, and serum samples collection. Results The median TSH was 2.04 mIU/L, P25=1.36 mIU/L, P75=2.99 mIU/L. TSH levels being normal, higher, and lower than the reference were 91.47%, 6.20%, and 2.33%, respectively. In Northeast Chongqing, the proportions of median TSH level and TSH level above the upper limit were higher than those in other regions(P<0.05). With improved education, proportions of TSH above the upper limit and below the lower limit declined(P<0.05). With the increase in body mass index, the proportion of those whose TSH was above the upper limit showed elevated trend(P<0.05). In women with history of adverse pregnancy outcomes, their median TSH was higher than that in the control group, and those, whose TSH level exceeded the upper limit, yield higher results than those in the control group(P<0.05). In women with higher fasting blood glucose The median TSH level was lower than that in normal blood glucose group(P<0.05), with the fasting plasma glucose concentration and TSH negatively correlated(P<0.05). Conclusion The abnormal rate of TSH level in planned pregnant women was 8.53% in Chongqing. The abnormal rate varies by different regions, education levels, body mass indexes, and blood glucose levels. Previous history of adverse pregnancy outcomes was related to elevated TSH levels. It is necessary to take pre-pregnancy thyroid function screening investigation. (Chin J Endocrinol Metab, 2015, 31: 510-514) Key words: Planned pregnancy; Thyroid stimulating hormone; Screening