Abstract
A new technique to destroy the gas‐filled capsule is proposed, making use of the collapsing bubble near the capsule in the ultrasound field. At the moment of collapses under the ultrasound irradiation, the bubble causes flow and acoustic wave radiation. These phenomena are expected to assist the destruction of the capsule. We observed the effect of the bubble on this destruction, using a high‐speed video camera which enables the real‐time imaging. In this experiment, we use gas‐filled capsule made of polyvinyl chloride. When no bubble was near the capsule at sound pressure of 60kPa, the capsule showed no vibration. However, in the presence of neighboring bubble, the capsule showed the destruction behavior of the deformation and the emission of internal gas. At higher sound pressure such as over 100kPa, the capsule showed above destruction behavior even if the bubble was not located near the capsule. In the presence of the bubble, however, the capsule was destructed in a shorter time. These experimental results give significant knowledge to a technique manipulating the gas‐filled capsule destruction in the drug delivery system.
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