Desmopressin response in nocturnal enuresis without nocturnal polyuria in Japanese children.

Abstract

To evaluate whether the efficacy of desmopressin differs between patients with and without nocturnal polyuria. A total of 65 treatment-naïve children with monosymptomatic nocturnal enuresis were enrolled (45 boys; median age 8.9years). Patients received desmopressin as their first-line treatment. Four different standards were used (Akashi and Hoashi >0.9mL/kg/sleeping hour; Hamano >[age+2]×25×130% mL; the International Children's Continence Society >[age+1]×30×130% mL; and Rittig >[age+9]×20mL) to assess nocturnal polyuria. The effectiveness of desmopressin was compared between patients with and without nocturnal polyuria according to each standard. A response was defined as a reduction in wet nights of >50%. The desmopressin treatment efficacy rate was 54% for polyuria and 67% for non-polyuria patients (P=0.20), 45% for polyuria and 68% for non-polyuria patients (P=0.08), 54% for polyuria and 59% for non-polyuria patients (P=0.80), and 52% for polyuria and 61% for non-polyuria patients (P=0.61), for the Akashi and Hoashi's, Hamano's, International Children's Continence Society and Rittig's standards, respectively. No difference was observed in the short-term clinical efficacy of desmopressin regardless of the presence of nocturnal polyuria. Thus, this might be a feasible treatment option for patients with nocturnal enuresis without nocturnal polyuria.