Abstract
Chemotherapy against specific molecular targets is one of the most effective approaches used to treatcancer patients. However, lack of selectivity and development of drug-resistance reduces the efficacyof cancer chemotherapy. Therefore, development of effective and safe anticancer agents with highpotency and less toxicity is a major focus for researchers across the world. In the current article, theutility of a reverse ligand similarity based approach to identify potential targets for a new series ofsynthesized pyrazole carbothioamides that demonstrate the potent anticancer activities against MCF-7 cells compared to other structurally related molecules and controls is discussed. Further, in silicodocking analysis provided insights into their sight of binding. Thus, these compounds show promise fordevelopment as next generation anticancer drugs.
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