Abstract

A methodical approach to synthesize several novel 2-phenyl-4-methylfuran [2,3-e][1,2,4]triazolo [1,5-c]pyrimidine derivatives (5a-c) as final compounds, N-(4-imino-4-methylfuro [2,3-d]pyrimidin-3(4H)-ylbenzamides (4a-c) by involving 2-amino-3-cyano-4-methyl furan (1) and N-(3-cyano-4-methylfuran)formimidic ethyl ether (2) and N’-((Z-(3-cyano-4-methylfuran-2-ylimino)methyl)benzohydrazides (3a-c) as intermediates and their antibacterial activity was tested. The chemical structures of all the newly synthesized intermediates and title compounds have been characterized by 1H NMR, IR, HRMS and elemental analysis. Compounds 4a-c and 5a-c showed antibacterial activity against different bacterial strains.

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