Abstract
Considering the future trends of biomaterials, current studies are focused on the corrosion resistance and the mechanical properties of new materials that need to be considered in the process of strengthening alloys with additive non-toxic elements. Many kinds of titanium alloys with different biocompatible elements (Mo, Si, Zr, etc.,) have been recently developed for their similar properties with human bone. Four new different alloys were obtained and investigated regarding their microstructure, mechanical, chemical, and biological behavior (in vitro and in vivo evaluation), the alloys are as follows: Ti15Mo7Zr15Ta, Ti15Mo7Zr15Ta0.5Si, Ti15Mo7Zr15Ta0.75Si, and Ti15Mo7Zr15Ta1Si. There were changes with the addition of the silicon element such as the hardness and the modulus of elasticity increased. An MTT assay confirmed the in vitro cytocompatibility of the prepared alloys.
Highlights
Some studies have shown that OPN can promote the secretion of MMP to increase the cell migration and cellfrom adhesion by inducing the secretion regulation of MMP-9
Theinto bone cells which express the OPN, MMP-9, or MMP-2 new alloyed account: the influence of the chemical elements on the and mechanical properties, and the level ofofbiocompatibility theduring body are chemical actively involved in the production and degradation the extracellularwith matrix tissues and the corrosion bone remodeling
For example: 50% higher weight resistance ratio than stainless steel, 50% lower young modulus than stainless steel and Co-Cr alloys, etc
Summary
For the selection of biomaterials, in order to fabricate an implant, it is necessary to take into account a multitude of factors such as: economic, mechanical, electrical, environmental (chemical), safety (biological), thermal, surface, aesthetic, performance, and research [2,3]. Metals are some of the most widely used biomaterials for orthopedic implants, and more applications. They are known for their high wear resistance, ductility, and high hardness. The most commonly used metals for making implants are titanium and titanium alloys, stainless steels, and cobalt-chromium-molybdenum alloys. Titanium and its alloys are especially used to fabricate orthopedic implants due to the fact that its mechanical properties are similar to those of bone tissue [6,7]
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