Abstract
Because the available avian leukosis viral (ALV) vectors are moderately oncogenic in vivo, they are no t suitable for insertion into the germ line. A significant reduction in the oncogenicity of the ALV vectors can be achieved by substituting the noncoding long terminal repeats (LTR) regions of the ALV virus with the LTR of the nononcogenic endogenous RAV-O virus. There is good evidence that the resulting RAV-O LTR vectors can be inserted into the germ line of domestic chickens and have the potenital for inserting cloned sequences that can be used for poultry improvement.
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