Abstract
The performance of four haemoperfusion columns, containing polymer-coated activated charcoal, for removal of paracetamol, acetyl salicylic acid and sodium amylobarbitone has been examined. Dye-tracer studies were used to measure mean residence times, dispersion coefficients and dead volumes of the columns. The mass-transfer coefficients for the removal of these substances from blood were measured to define the importance of the boundary layer in determining the kinetics of extraction. Diffusion through this layer was found to be the rate-limiting step for paracetamol adsorption, but other factors also were found to be of importance for the other two substances. The results suggest that an efficient perfusion column would consist of a long, thin configuration rather than a squat, short shape.
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