Abstract
Studies were carried out to develop, characterize and compare oral floating microspheres for Eletriptan Hydrobromide using Ion exchange resin like Cholestyramine and low density porous carrier like calcium silicate so as to provide extended gastric retention. The prepared resinates were studied for the effect of pH and drug resin ratio on drug loading and is similar with calcium silicate. Both the formulations were evaluated for drug entrapment, in vitro floating behavior, in vivo buoyancy and in vitro drug release studies. Dissolution study of Eletriptan hydrobromide microspheres with both the calcium silicate and cholestyramine was able to sustain the release of the drug. The study suggests that the floating microspheres of Eletriptan hydrobromide provide sustained release over 24 h and also showed in vivo buoyancy for more than 10 h in rabbit.
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