Design and synthesis of ferrocene‐based magnetic nanoparticle and investigation of its catalytic ability in the synthesis of novel 6‐[(morpholin‐4‐yl)methyl] substituted pyrano[3,2‐b]pyran derivatives

Abstract

In this work, we designed and synthesized the Fe3O4@SiO2@(CH2)3‐Im‐bisethylFc (CH3CO2) as a new catalyst for three‐multicomponent reaction (t‐MCR), which is a silica‐coated Fe3O4 nanoparticle supported with bisethylferrocene‐containing IL. All of the prepared nanoparticles were specified using FT‐IR spectroscopy, FE‐SEM, XRD, TEM, and EDX techniques. The activity of the final modified nanoparticle as MCR catalyst was tested in the one‐pot procurement of novel pyran derivatives through a t‐MCR between 2‐[(morpholin‐4‐yl)methyl]‐5‐hydroxy‐4H‐pyran‐4‐one, malononitrile, and diversity of aromatic aldehydes. The compound 2‐[(morpholin‐4‐yl)methyl]‐5‐hydroxy‐4H‐pyran‐4‐one as a precursor, was prepared via nucleophilic substitution reaction of morpholine with chlorokojic acid. The FT‐IR, 1H, and 13C NMR spectroscopies were used for the identification of newly synthesized compounds.