Design and synthesis of Capecitabine-tris(nonofluoro tert-butyl) a highly symmetrical fluorinated hydrocarbons as multifunctional image-guided drug delivery vehicles using CuAAC reaction

Abstract

In the light of extensive versatility of application of controlled release and formulations, in the field of medical and pharmaceutical sciences, they are unavoidable tools for theexploitation of the modern concept of therapeutictreatment whose aim is toincrease drug effectiveness and patient compliance, to reduce the administration frequency and side effects connected to dosingand toxicity of healthy cells. As a matter of fact, controlled release formulations bring engineers and pharmacists to worktogether with the common aim of realizing more andmore effective therapeuticproducts. The healthy cells may also need to succeedand avoid apoptosis, anticancer agents can be toxic to such cells. To minimize these toxicities, approaches have been developed wherein the therapeutic agent is targeted to tumor cells through conjugation to a tumor-cell-specific small-molecule ligand, thus reducing delivery to normal cells and the associated collateral toxicity. Herein we describes the novel Capecitabine-tris(nonofluoro tert-butyl)derived a highly symmetrical fluorinated hydrocarbonsdrug delivery systemin the design of ligand-targeted drugs and ligand–drug conjugates and ligand–imaging-agent conjugatesare described.