Abstract
Cyclodextrins-based nanocarriers are versatile formulations used for drug delivery applications. These nanosponge formulations are hyper-cross-linked polymer structures used to improve the solubility and bioavailability of various poorly soluble drugs. Rosuvastatin is an anti-hyperlipidemic drug that acts by inhibiting of β-hydroxy β-methyl glutaryl-CoA (HMG CoA) reductase enzyme, which is essential for cholesterol synthesis, that is used to treat hyperlipidemia, a condition that has elevated cholesterol levels. In the present study, Rosuvastatin was synthesized by the emulsion solvent evaporation method to prepare nanosponges using polymers ethylcellulose and β-cyclodextrin and evaluated for particle size, and surface morphology using scanning electron microscopy, zeta potential, drug-excipient compatibility using Fourier Transmission Infrared Spectroscopy (FTIR). Apart from these, entrapment efficiency, drug release, and release kinetics were also studied. Nine formulations using different concentrations of polymers were prepared. The best formulation (R showed the average particle size was 386 nm, entrapment efficiency calculated showed 75.45, and drug release was 99.77 % at 8 h drug release kinetics showing zero-order drug release and Higuchi diffusion mechanism.
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